Also known as LAT1, pp36, linker for activation of T-cells, IMD52, linker for activation of T cells
protein-coding gene in the species Homo sapiens
Gene data
LAT- Name
- linker for activation of T cells
- Type
- protein-coding
- Position
- 28,984,808–28,990,784 (+)
- Aliases
- IMD52, LAT1, pp36
- Ensembl
- ENSG00000213658
- RefSeq RNA
- NM_001014987.2, NM_001014988.2, NM_001014989.2, NM_014387.4
- RefSeq protein
- NP_001014987.1, NP_001014988.1, NP_001014989.2, NP_055202.1
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
linker for activation of T cells
- Symbol
- LAT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:28,984,808-28,990,784
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 7811
- exact match
- identifiers.org/ncbigene/27040
- genomic end
- 28990784
- genomic start
- 28996147
- cytogenetic location
- 16p11.2
Sources (4)
via Wikidata · CC0