VAV1

Name

vav guanine nucleotide exchange factor 1

Type

protein-coding

Position

6,772,676–6,857,366 (+)

Aliases

VAV

Ensembl

ENSG00000141968

RefSeq RNA

NM_001258206.2, NM_001258207.2, NM_005428.4, XM_005259642.2, XM_054321944.1

RefSeq protein

NP_001245135.1, NP_001245136.1, NP_005419.2, XP_005259699.1, XP_054177919.1

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

via MyGene.info

Gene · Ensembl

vav guanine nucleotide exchange factor 1

Symbol

VAV1

Biotype

Protein coding

Organism

Homo sapiens

Location

19:6,772,676-6,857,366

Strand

Forward (+)

Assembly

GRCh38