VAV1

Also known as VAV, vav guanine nucleotide exchange factor 1

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.

Gene data

VAV1

Name: vav guanine nucleotide exchange factor 1
Type: protein-coding
Aliases: VAV

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

via MyGene.info