BAG3

Also known as BAG-3, BIS, CAIR-1, MFM6, BCL2 associated athanogene 3, BAG cochaperone 3

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy.

Gene data

BAG3

Name: BAG cochaperone 3
Type: protein-coding
Aliases: BAG-3, BIS, CAIR-1, CMD1HH, CMT2JJ, HMND15, MFM6

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

BAG cochaperone 3

Symbol: BAG3
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:119,650,879-119,677,913
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein BAG3 PDB 1uk5.png

Show 5 more facts

HomoloGene ID: 3162
exact match: identifiers.org/ncbigene/9531
genomic end: 121437331
genomic start: 119651380
cytogenetic location: 10q26.11

Sources (8)

via Wikidata · CC0

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Article

6 sections

Contents

Function
Clinical significance
Interactions
References
Further reading
External links

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy.

== Function ==