MAPK1
Sign in to saveAlso known as ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.
Gene data
MAPK1- Name
- mitogen-activated protein kinase 1
- Type
- protein-coding
- Position
- 21,755,537–21,867,680 (−)
- Aliases
- ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38
- Ensembl
- ENSG00000100030
- RefSeq RNA
- NM_002745.5, NM_138957.3
- RefSeq protein
- NP_002736.3, NP_620407.1
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase 1
- Symbol
- MAPK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:21,755,537-21,867,680
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein MAPK1 PDB 1erk.png
Show 6 more facts
- HomoloGene ID
- 5594
- exact match
- identifiers.org/ncbigene/5594
- genomic end
- 22221970
- genomic start
- 21759657
- cytogenetic location
- 22q11.22
- Commons category
- Extracellular signal-regulated kinase 2
via Wikidata · CC0
~2 min read
Article
7 sectionsContents
- Function
- Interactions
- Clinical significance
- See also
- References
- Further reading
- External links
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.
== Function == The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.