ITPK1

Also known as ITRPK1, inositol-tetrakisphosphate 1-kinase

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

Gene data

ITPK1

Name: inositol-tetrakisphosphate 1-kinase
Type: protein-coding
Position: 92,936,914–93,116,458 (−)
Aliases: ITRPK1
Ensembl: ENSG00000100605
RefSeq RNA: NM_001142593.3, NM_001142594.3, NM_001363707.2, NM_014216.6, XM_017021262.2
RefSeq protein: NP_001136065.1, NP_001136066.1, NP_001350636.1, NP_055031.2, XP_016876751.2

This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016].

Gene Ontology

Biological process

signal transduction

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Article

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Contents

References
Further reading

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.