ITPK1

Also known as ITRPK1, inositol-tetrakisphosphate 1-kinase

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to ITPK1, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Vinony links it to 6 Wikipedia language editions.

Gene data

ITPK1

Name: inositol-tetrakisphosphate 1-kinase
Type: protein-coding
Position: 92,927,110–93,116,458 (−)
Aliases: ITRPK1
Ensembl: ENSG00000100605
RefSeq RNA: NM_001142593.3, NM_001142594.3, NM_001363707.2, NM_014216.6, XM_017021262.2
RefSeq protein: NP_001136065.1, NP_001136066.1, NP_001350636.1, NP_055031.2, XP_016876751.2

This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016].

Gene Ontology

Biological process

signal transduction blood coagulation inositol trisphosphate metabolic process necroptotic process

Molecular function

magnesium ion binding inositol-1,3,4,5-tetrakisphosphate 6-kinase activity catalytic activity protein binding ATP binding metal ion binding inositol-3,4,5,6-tetrakisphosphate 1-kinase activity inositol-3,4,5,6-tetrakisphosphate 1-kinase activity

Cellular component

cytoplasm cytosol apical plasma membrane

Pathways

Inositol phosphate metabolism - Homo sapiens (human)Phosphatidylinositol signaling system - Homo sapiens (human)Hemostasis Metabolism Inositol phosphate metabolism Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production

via MyGene.info

Gene · Ensembl

inositol-tetrakisphosphate 1-kinase

Symbol: ITPK1
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:92,927,110-93,116,458
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein ITPK1 PDB 2odt.png

Show 8 more facts

HomoloGene ID: 8588
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3705
chromosome: human chromosome 14
genomic start: 93403259
genomic end: 93582665
cytogenetic location: 14q32.12
expressed in: caudate nucleus

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.

Excerpted from Wikipedia’s “ITPK1” article, available under the CC BY-SA 4.0 licence.