IMPDH1
Sign in to saveAlso known as IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608, IMP (inosine 5'-monophosphate) dehydrogenase 1, inosine monophosphate dehydrogenase 1
'''Inosine-5'-monophosphate dehydrogenase 1, also known as IMP dehydrogenase 1', is an enzyme that in humans is encoded by the IMPDH1'' gene.
Gene data
IMPDH1- Name
- inosine monophosphate dehydrogenase 1
- Type
- protein-coding
- Aliases
- IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
via MyGene.info
Gene · Ensembl
inosine monophosphate dehydrogenase 1
- Symbol
- IMPDH1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:128,392,277-128,410,009
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- PDB 1jcn EBI.jpg
Show 5 more facts
- HomoloGene ID
- 68096
- exact match
- identifiers.org/ncbigene/3614
- genomic start
- 128032331
- genomic end
- 128050306
- cytogenetic location
- 7q32.1
Sources (3)
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Clinical significance
- See also
- References
- Further reading
- External links
'''Inosine-5'-monophosphate dehydrogenase 1, also known as IMP dehydrogenase 1', is an enzyme that in humans is encoded by the IMPDH1'' gene.
== Function ==