PCK1
Sign in to saveAlso known as PEPCK-C, PEPCK1, PEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.
Gene data
PCK1- Name
- phosphoenolpyruvate carboxykinase 1
- Type
- protein-coding
- Position
- 57,546,220–57,570,667 (+)
- Aliases
- PCKDC, PEPCK-C, PEPCK1, PEPCKC
- Ensembl
- ENSG00000124253
- RefSeq RNA
- NM_002591.4, XM_024451888.2, XM_054323468.1
- RefSeq protein
- NP_002582.3, XP_024307656.1, XP_054179443.1
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
phosphoenolpyruvate carboxykinase 1
- Symbol
- PCK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:57,546,220-57,570,667
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactive pathway map
- See also
- References
- Further reading
Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.
== Function==
Excerpted from Wikipedia’s “PCK1” article, available under the CC BY-SA 4.0 licence.