Also known as CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, pyruvate kinase, muscle
Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.
Gene data
PKM- Name
- pyruvate kinase M1/2
- Type
- protein-coding
- Position
- 72,199,026–72,231,819 (−)
- Aliases
- CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58
- Ensembl
- ENSG00000067225
- RefSeq RNA
- NM_001206796.3, NM_001206797.3, NM_001206798.3, NM_001206799.2, NM_001316318.2
- RefSeq protein
- NP_001193725.1, NP_001193726.1, NP_001193727.1, NP_001193728.1, NP_001303247.1
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pyruvate kinase M1/2
- Symbol
- PKM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:72,199,024-72,231,819
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PKM2 PDB 1a49.png
Show 5 more facts
- HomoloGene ID
- 37650
- exact match
- identifiers.org/ncbigene/5315
- genomic end
- 72231819
- genomic start
- 72491370
- cytogenetic location
- 15q23
via Wikidata · CC0
~15 min read
Article
16 sectionsContents
- Discovery
- Structure
- Function
- Localization
- Tissue
- Cellular
- Subcellular
- Clinical significance
- Bi-functional role within tumors
- Natural mutations and carcinogenesis
- Regulatory circuits
- Bacterial pathogenesis
- Interactive pathway map
- See also
- References
- External links
Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.
PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.