ENO1
Sign in to saveAlso known as ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1.
Gene data
ENO1- Name
- enolase 1
- Type
- protein-coding
- Position
- 8,860,977–8,879,289 (−)
- Aliases
- ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
- Ensembl
- ENSG00000074800
- RefSeq RNA
- NM_001201483.4, NM_001353346.3, NM_001428.5
- RefSeq protein
- NP_001188412.1, NP_001340275.1, NP_001419.1
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
enolase 1
- Symbol
- ENO1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:8,854,043-8,879,308
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein ENO1 PDB 2PSN.png
Show 5 more facts
- HomoloGene ID
- 134343
- exact match
- identifiers.org/ncbigene/2023
- genomic end
- 8879190
- genomic start
- 8861000
- cytogenetic location
- 1p36.23
Sources (4)
via Wikidata · CC0
~6 min read
Article
13 sectionsContents
- Structure
- Relationship to Myc-binding protein-1
- Function
- Clinical significance
- Cancer
- Autoimmune disease
- Gastrointestinal disease
- Hemolytic anemia
- Interactive pathway map
- Interactions
- See also
- External links
- References
Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.
== Structure == ENO1 is one of three enolase isoforms, the other two being ENO2 (ENO-γ) and ENO3 (ENO-β). Each isoform is a protein subunit that can hetero- or homodimerize to form αα, αβ, αγ, ββ, and γγ dimers. The ENO1 gene spans 18 kb and lacks a TATA box while possessing multiple transcription start sites. A hypoxia-responsive element can be found in the ENO1 promoter and allows the enzyme to function in aerobic glycolysis and contribute to the Warburg effect in tumor cells.