oncogenomics

Also known as cancer genomics

Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes. It focuses on genomic, epigenomic and transcript alterations in cancer.

~28 min read

Article

21 sections

Contents

History
Whole genome sequencing
Technologies
Genome sequencing
Transcriptomes
Bioinformatics and functional analysis of oncogenes
Operomics
Comparative oncogenomics
Source of cancer driver mutations, cancer mutagenesis
Synthetic lethality
Databases for cancer research
Gene families
Mitochondrial DNA
Point mutations
Deletions
Insertions
Copy number mutations
Diagnostic applications
Cancer biomarkers
See also
References

Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes. It focuses on genomic, epigenomic and transcript alterations in cancer.

Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.