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genomics
Sign in to saveAlso known as genomic science, genome science, genome sciences
Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assis
Genomics is the study of all the DNA in an organism—not just individual genes, but how they work together and influence the organism as a whole. This field matters because understanding the complete genetic blueprint and how genes interact helps scientists learn about disease, evolution, and potentially develop new treatments.
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Research
2,126,050 papers- Plant pan-genomics: recent advances, new challenges, and roads ahead.ReviewJournal of genetics and genomics = Yi chuan xue bao · 2022Li W, Liu J, Zhang H et al.DOI: 10.1016/j.jgg.2022.06.004
- Computational Genomics and Its Applications to Anthropological Questions.ReviewAmerican journal of biological anthropology · 2024Witt KE, Villanea FADOI: 10.1002/ajpa.70010
- Ancestral Population Genomics.ReviewMethods in molecular biology (Clifton, N.J.) · 2019Dutheil JY, Hobolth ADOI: 10.1007/978-1-4939-9074-0_18
- Insect Mitochondrial Genomics: A Decade of Progress.ReviewAnnual review of entomology · 2025Cameron SLDOI: 10.1146/annurev-ento-013024-015553
- The Genomics Revolution Drives a New Era in Entomology.ReviewAnnual review of entomology · 2025Li F, Wang X, Zhou XDOI: 10.1146/annurev-ento-013024-013420
- A phylogenetic approach to comparative genomics.ReviewNature reviews. Genetics · 2025Dewar AE, Belcher LJ, West SADOI: 10.1038/s41576-024-00803-0
- Blowfly genomics: current insights, knowledge gaps, and future perspectives.ReviewCurrent opinion in insect science · 2025Parmar DR, Johnston NP, Wallman JF et al.DOI: 10.1016/j.cois.2024.101305
- A decade of dinoflagellate genomics illuminating an enigmatic eukaryote cell.ReviewBMC genomics · 2024Lin SDOI: 10.1186/s12864-024-10847-5
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Article
31 sectionsContents
- History
- Etymology
- Early sequencing efforts
- DNA-sequencing technology developed
- Complete genomes
- The "omics" revolution
- Genome analysis
- Sequencing
- Shotgun sequencing
- High-throughput sequencing
- Assembly
- Assembly approaches
- Finishing
- Annotation
- Sequencing pipelines and databases
- Research areas
- Functional genomics
- Structural genomics
- Epigenomics
- Metagenomics
- Model systems
- Viruses and bacteriophages
- Cyanobacteria
- Applications
- Genomic medicine
- Synthetic biology and bioengineering
- Population and conservation genomics
- See also
- References
- Further reading
- External links
Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain.
The field also includes studies of intragenomic (within the genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and other interactions between loci and alleles within the genome.