Hexokinase 2
Sign in to saveAlso known as hexokinase-B, HK II, hexokinase-2, muscle form hexokinase, hexokinase type II, hexokinase-2, muscle, HK2
mammalian protein found in Homo sapiens
Protein · UniProt
Hexokinase-2
- Gene
- HK2
- Organism
- Homo sapiens (Human)
- Length
- 917 aa
- Molecular mass
- 102,380 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
2 registered- NACOMPLETEDMaximal Fat Oxidation and Fuel Use During ExerciseUniversity of Copenhagen · NCT04678713
- EARLY_PHASE1NOT_YET_RECRUITINGAzoles Targeting Recurrent High Grade GliomasUniversity Health Network, Toronto · NCT03763396