CSK

Name

C-terminal Src kinase

Type

protein-coding

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017].

via MyGene.info

Gene · Ensembl

C-terminal Src kinase

Symbol

CSK

Biotype

Protein coding

Organism

Homo sapiens

Location

15:74,782,023-74,804,177

Strand

Forward (+)

Assembly

GRCh38

• CSK-mediated signalling by integrins in cancer.Frontiers in cell and developmental biology · 2023
• Regulation, targets and functions of CSK.Frontiers in cell and developmental biology · 2023
• Apoptosis regulation by the tyrosine-protein kinase CSK.Frontiers in cell and developmental biology · 2022
• Csk-mediated Src family kinase regulation dampens neutrophil infiltration during pulmonary infection.JCI insight · 2025
• Editorial: Regulation and dysfunction of CSK and CHK.Frontiers in cell and developmental biology · 2023

via PubMed

Wikidata facts

Image

PBB Protein SRC image.jpg

via Wikidata · CC0