NTRK3

Name

neurotrophic receptor tyrosine kinase 3

Type

protein-coding

Aliases

GP145-TrkC, TRKC, gp145(trkC)

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

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Gene · Ensembl

neurotrophic receptor tyrosine kinase 3

Symbol

NTRK3

Biotype

Protein coding

Organism

Homo sapiens

Location

15:87,859,751-88,256,993

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein NTRK3 PDB 1wwc.png

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