Also known as LCK proto-oncogene, Src family tyrosine kinase, IMD22, LSK, YT16, p56lck, pp58lck
protein-coding gene in the species Homo sapiens
Gene data
LCK- Name
- LCK proto-oncogene, Src family tyrosine kinase
- Type
- protein-coding
- Position
- 32,251,244–32,286,170 (+)
- Aliases
- IMD22, LSK, YT16, p56lck, pp58lck
- Ensembl
- ENSG00000182866
- RefSeq RNA
- NM_001042771.3, NM_001330468.2, NM_001439146.1, NM_005356.5, XM_011541453.3
- RefSeq protein
- NP_001036236.1, NP_001317397.1, NP_001426075.1, NP_005347.3, XP_011539755.1
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
LCK proto-oncogene, Src family tyrosine kinase
- Symbol
- LCK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:32,251,244-32,286,170
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 1lkkA SH2 domain.png
Show 6 more facts
- HomoloGene ID
- 3911
- exact match
- identifiers.org/ncbigene/3932
- genomic end
- 32751766
- genomic start
- 32716840
- Commons category
- Lymphocyte specific protein tyrosine kinase p56
- cytogenetic location
- 1p35.2
via Wikidata · CC0