ZAP70

Also known as SRK, STCD, STD, TZK, ZAP-70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T-cell receptor associated protein kinase 70

ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.

Gene data

ZAP70

Name: zeta chain of T cell receptor associated protein kinase 70
Type: protein-coding
Position: 97,713,576–97,744,327 (+)
Aliases: ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70
Ensembl: ENSG00000115085
RefSeq RNA: NM_001079.4, NM_001378594.1, NM_001446009.1, NM_001446011.1, NM_001446012.1
RefSeq protein: NP_001070.2, NP_001365523.1, NP_001432938.1, NP_001432940.1, NP_001432941.1

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways

via MyGene.info

Gene · Ensembl

zeta chain of T cell receptor associated protein kinase 70

Symbol: ZAP70
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:97,713,190-97,744,327
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ZAP70 PDB 1m61.png

Show 5 more facts

HomoloGene ID: 839
exact match: identifiers.org/ncbigene/7535
genomic end: 98356325
genomic start: 97713576
cytogenetic location: 2q11.2

Sources (6)

via Wikidata · CC0

~5 min read

Article

7 sections

Contents

Function
Clinical significance
Interactions
See also
References
Further reading
External links

ZAP-70 was initially discovered in TCR-stimulated Jurkat cells, an immortal line of human T lymphocytes, in 1991. Its molecular weight is 70 kDa, and it is a member of the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the jawed vertebrates. The importance of ZAP-70 in T cell activation was determined when comparing ZAP-70 expression in patients with SCID (severe combined immunodeficiency). ZAP-70 deficient individuals were found to have no functioning T cells in their peripheral blood, suggesting that ZAP-70 is a critical component of T cell activation and development.