GPR78

Also known as G protein-coupled receptor 78

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene.

In the Vinony graph

Within Vinony's link graph, GPR78 is referenced by 488 other articles, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

It is catalogued under topics including Genes on human chromosome 4 and G protein-coupled receptors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

GPR78

Name: G protein-coupled receptor 78
Type: protein-coding
Position: 8,558,725–8,619,761 (+)
Ensembl: ENSG00000155269
RefSeq RNA: NM_080819.5, NR_045511.3
RefSeq protein: NP_543009.2

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway

Molecular function

G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity protein binding

Cellular component

plasma membrane membrane

via MyGene.info

Gene · Ensembl

G protein-coupled receptor 78

Symbol: GPR78
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:8,558,725-8,619,761
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 50960
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/27201
genomic end: 8621486
genomic start: 8560452
chromosome: human chromosome 4
cytogenetic location: 4p16.1
expressed in: prefrontal cortex

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene.

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]

Excerpted from Wikipedia’s “GPR78” article, available under the CC BY-SA 4.0 licence.