File:Rhodopsin.png · Wikimedia Commons · See Wikimedia Commons
rhodopsin
Sign in to saveAlso known as opsin 2, rod pigment, opsin-2, IPR000732, visual purple, RHO
Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor (GPCR). It is a light-sensitive receptor protein that triggers visual phototransduction in rod cells. Rhodopsin mediates dim light vision and thus is extremely sensitive to light. When rhodopsin is exposed to light, it immediately photobleaches. In humans, it is fully regenerated in about 30 minutes, after which the rods are more sensitive. Defects in the rhodopsin gene cause eye diseases such as retinitis pigmentosa and congenital stationary night blindness.
Protein · UniProt
Rhodopsin
- Gene
- RHO
- Organism
- Homo sapiens (Human)
- Length
- 348 aa
- Molecular mass
- 38,893 Da
- Evidence
- 1: Evidence at protein level
G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions (PubMed:6140680, PubMed:7846071, PubMed:8107847). Required for postnatal photoreceptor cell viability (PubMed:12566452, PubMed:2215617). Activation occurs when the covalently bound 11-cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers G protein-mediated phototransduction (Probable) (PubMed:26200343, PubMed:28753425, PubMed:8…
Swiss-Prot (reviewed) · via UniProt
Research
13,117 papersvia PubMed
Clinical Trials
8 registered- PHASE1/PHASE2ACTIVE_NOT_RECRUITINGStudy to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital AmaurosisOcugen · NCT05203939
- PHASE2COMPLETEDA Study in Subjects With Retinitis PigmentosaAldeyra Therapeutics, Inc. · NCT05392179
- EARLY_PHASE1UNKNOWNSafety and Tolerability Study of Gene Editing Drug ZVS203e in Participants With Retinitis PigmentosaPeking University Third Hospital · NCT05805007
- PHASE1/PHASE2ACTIVE_NOT_RECRUITINGA Phase 1/2 Study in Healthy Volunteers and Participants With Autosomal Dominant Retinitis Pigmentosa (RHO-adRP)Octant, Inc. · NCT07408232
- PHASE1/PHASE2NOT_YET_RECRUITINGSafety and Efficacy of ZVS203e in the Treatment of Retinitis Pigmentosa Caused by RHO Gene MutationChigenovo Co., Ltd · NCT06952842
- PHASE1/PHASE2RECRUITINGGVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle GlaucomaIVIEW Therapeutics Inc. · NCT06921317
Wikidata facts
- Image
- Rhodopsin 3D.jpeg
Show 3 more facts
- Commons category
- Rhodopsins
- HomoloGene ID
- 68068
- exact match
- purl.uniprot.org/uniprot/P08100
via Wikidata · CC0
~9 min read
Article
13 sectionsContents
- History
- General
- Structure
- Phototransduction
- Activation
- Phototransduction cascade
- Deactivation
- Diseases of the retina
- See also
- Explanatory notes
- References
- Further reading
- External links
Rhodopsin, also known as visual purple, is a protein encoded by the RHO gene and a G-protein-coupled receptor (GPCR). It is a light-sensitive receptor protein that triggers visual phototransduction in rod cells. Rhodopsin mediates dim light vision and thus is extremely sensitive to light. When rhodopsin is exposed to light, it immediately photobleaches. In humans, it is fully regenerated in about 30 minutes, after which the rods are more sensitive. Defects in the rhodopsin gene cause eye diseases such as retinitis pigmentosa and congenital stationary night blindness.
== History ==