GPR149

Also known as IEDA, PGR10, G protein-coupled receptor 149, R35

Probable G-protein coupled receptor 149 is a protein that in humans is encoded by the GPR149 gene.

In the Vinony graph

Vinony's link graph records 485 inbound references to GPR149, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

Vinony files it under Genes on human chromosome 3 and G protein-coupled receptors.

Vinony links it to 5 Wikipedia language editions.

Gene data

GPR149

Name: G protein-coupled receptor 149
Type: protein-coding
Position: 154,334,943–154,430,190 (−)
Aliases: IEDA, PGR10, R35
Ensembl: ENSG00000174948
RefSeq RNA: NM_001038705.3
RefSeq protein: NP_001033794.1

This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017].