GPR158
Sign in to saveAlso known as G protein-coupled receptor 158
Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR), is a protein that in humans is encoded by the GPR158 gene.
Gene data
GPR158- Name
- G protein-coupled receptor 158
- Type
- protein-coding
- Position
- 25,174,734–25,602,229 (+)
- Aliases
- mGlyR
- Ensembl
- ENSG00000151025
- RefSeq RNA
- NM_020752.3, XM_017016452.3, XR_008488243.1, XR_930512.4
- RefSeq protein
- NP_065803.2, XP_016871941.1
Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
G protein-coupled receptor 158
- Symbol
- GPR158
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:25,174,734-25,602,229
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 19381
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57512
- genomic end
- 25602229
- genomic start
- 25174802
- chromosome
- human chromosome 10
- cytogenetic location
- 10p12.1
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Role in mood regulation
- Role in prostate cancer
- References
Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR), is a protein that in humans is encoded by the GPR158 gene.
==Function== This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.
Excerpted from Wikipedia’s “GPR158” article, available under the CC BY-SA 4.0 licence.