FLT1

Name

fms related receptor tyrosine kinase 1

Type

protein-coding

Position

28,300,346–28,495,145 (−)

Aliases

FLT, FLT-1, VEGFR-1, VEGFR1

Ensembl

ENSG00000102755

RefSeq RNA

NM_001159920.2, NM_001160030.2, NM_001160031.1, NM_001445916.1, NM_002019.4

RefSeq protein

NP_001153392.1, NP_001153502.1, NP_001153503.1, NP_001432845.1, NP_002010.2

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009].

via MyGene.info

Gene · Ensembl

fms related receptor tyrosine kinase 1

Symbol

FLT1

Biotype

Protein coding

Organism

Homo sapiens

Location

13:28,299,540-28,495,288

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein FLT1 PDB 1flt.png

via Wikidata · CC0