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GeneQ18034561· pop 5· linked from 35 articles

CEP135

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Also known as CEP4, KIAA0635, MCPH8, centrosomal protein 135

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. CEP135 is required for the centriolar localization of CEP250.

Gene data

CEP135
Name
centrosomal protein 135
Type
protein-coding
Position
55,948,819–56,033,361 (+)
Aliases
CEP4, KIAA0635, MCPH8
Ensembl
ENSG00000174799
RefSeq RNA
NM_014645.1, NM_025009.5, XM_005265788.5, XM_006714055.4, XM_011534412.2
RefSeq protein
NP_079285.2, XP_005265845.1, XP_006714118.1, XP_011532714.1, XP_054207279.1

This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012].

Gene Ontology

Pathways

Cell CycleOrganelle biogenesis and maintenanceRegulation of PLK1 Activity at G2/M TransitionLoss of Nlp from mitotic centrosomesRecruitment of mitotic centrosome proteins and complexesLoss of proteins required for interphase microtubule organization from the centrosomeCentrosome maturationRecruitment of NuMA to mitotic centrosomesMitotic G2-G2/M phasesCilium Assembly

via MyGene.info

Gene · Ensembl

centrosomal protein 135

Symbol
CEP135
Biotype
Protein coding
Organism
Homo sapiens
Location
4:55,948,819-56,033,361
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
45709
genomic end
56033361
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/9662
genomic start
56815037
chromosome
human chromosome 4
cytogenetic location
4q12
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • References
  • External links
  • Further reading

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. CEP135 is required for the centriolar localization of CEP250.

==References==

Excerpted from Wikipedia’s “CEP135” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0