Also known as MVA2, PIG8, TSP57, centrosomal protein 57
Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene. It is also known as translokin.
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene. It is also known as translokin.
Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM]
Biological process
Molecular function
via MyGene.info
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).