ERBB4

Name

erb-b2 receptor tyrosine kinase 4

Type

protein-coding

Position

211,375,717–212,538,841 (−)

Aliases

ALS19, HER4, p180erbB4

Ensembl

ENSG00000178568

RefSeq RNA

NM_001042599.2, NM_001439005.1, NM_001439006.1, NM_005235.3, XM_006712364.4

RefSeq protein

NP_001036064.1, NP_001425934.1, NP_001425935.1, NP_005226.1, XP_006712427.1

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

erb-b2 receptor tyrosine kinase 4

Symbol

ERBB4

Biotype

Protein coding

Organism

Homo sapiens

Location

2:211,375,717-212,539,266

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein ERBB4 PDB 2ahx.png

via Wikidata · CC0