NRG1

Also known as ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, NRG1 is referenced by 380 other articles, and connects out to Q180686, Ensembl genome database project and ADCYAP1.

Vinony files it under Genes on human chromosome 8, Neurotrophic factors and Proteins.

Its subject is documented across 6 Wikipedia language editions.

Gene data

NRG1

Name: neuregulin 1
Type: protein-coding
Position: 31,639,222–32,855,666 (+)
Aliases: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF
Ensembl: ENSG00000157168
RefSeq RNA: NM_001159995.3, NM_001159996.3, NM_001159999.3, NM_001160001.3, NM_001160002.2
RefSeq protein: NP_001153467.1, NP_001153468.1, NP_001153471.1, NP_001153473.1, NP_001153474.1

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016].