GRAP

Also known as GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.

Gene data

GRAP

Name: GRB2 related adaptor protein
Type: protein-coding
Position: 19,020,656–19,047,143 (−)
Aliases: DFNB114
Ensembl: ENSG00000154016
RefSeq RNA: NM_001330148.2, NM_006613.4, XM_047435154.1, XM_047435155.1, XM_047435156.1
RefSeq protein: NP_001317077.1, NP_006604.1, XP_047291110.1, XP_047291111.1, XP_047291112.1

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

signal transduction Ras protein signal transduction Ras protein signal transduction cell-cell signaling sensory perception of sound regulation of MAPK cascade

Molecular function

phosphotyrosine residue binding epidermal growth factor receptor binding protein binding

Cellular component

nucleoplasm cytoplasm cytoplasm cytosol cytosol plasma membrane COP9 signalosome membrane

Pathways

Signaling by SCF-KIT Signal Transduction Signaling by Receptor Tyrosine Kinases

via MyGene.info

Gene · Ensembl

GRB2 related adaptor protein

Symbol: GRAP
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:19,020,656-19,047,143
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 4822
exact match: identifiers.org/ncbigene/10750
genomic end: 19047011
genomic start: 19020656
cytogenetic location: 17p11.2

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Further reading

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.