GRAP
Also known as GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114
GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.
Gene data
GRAP- Name
- GRB2 related adaptor protein
- Type
- protein-coding
- Position
- 19,020,656–19,047,143 (−)
- Aliases
- DFNB114
- Ensembl
- ENSG00000154016
- RefSeq RNA
- NM_001330148.2, NM_006613.4, XM_047435154.1, XM_047435155.1, XM_047435156.1
- RefSeq protein
- NP_001317077.1, NP_006604.1, XP_047291110.1, XP_047291111.1, XP_047291112.1
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Article
3 sectionsContents
- Interactions
- References
- Further reading
GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.
This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.