insulin receptor

Protein · UniProt

Insulin receptor

Gene

INSR

Organism

Homo sapiens (Human)

Length

1,382 aa

Molecular mass

156,333 Da

Evidence

1: Evidence at protein level

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signa…

• Insulin Receptor Trafficking: Consequences for Insulin Sensitivity and Diabetes.International journal of molecular sciences · 2019
• Tuning insulin receptor signaling using de novo-designed agonists.Molecular cell · 2025
• Insulin receptor--structural and functional characteristics.Medical science monitor : international medical journal of experimental and clinical research · 2001
• The aetiology and molecular landscape of insulin resistance.Nature reviews. Molecular cell biology · 2021
• Insulin receptor disorders in Japan.Diabetes research and clinical practice · 1994

via PubMed

• NAUNKNOWN
  Exenatide Plus Pioglitazone Versus Insulin in Poorly Controlled T2DMDr. Muhammad Abdulghani · NCT02887625
• PHASE1COMPLETED
  A Study of IMC-A12 in Participants With Tumors Who No Longer Respond to Treatment or For Whom No Treatment is AvailableEli Lilly and Company · NCT00785538
• PHASE4COMPLETED
  The Role of Acute Combined PPAR Alpha and Gamma Stimulation on Insulin Action in HumansAlbert Einstein College of Medicine · NCT00179400
• PHASE3ACTIVE_NOT_RECRUITING
  A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)Regeneron Pharmaceuticals · NCT06548100
• PHASE3COMPLETED
  Effect of Eplerenone on Endothelial Function in Metabolic SyndromeUniversity of Erlangen-Nürnberg Medical School · NCT01319344
• PHASE4COMPLETED
  The Effects of Peroxisome Proliferators Activated Receptor-Gamma (PPAR-γ) Agonists on Certain Biochemical and Inflammatory Markers in Metabolic SyndromeAligarh Muslim University · NCT00926341

via ClinicalTrials.gov