PABPC1
Sign in to saveAlso known as PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability. There are two separate PABP1 proteins, one which is located in the nucleus (PABPN1) and the other which is found in the cytoplasm (PABPC1). The location of PABP1 affects the role of that protein and its function with RNA.
Gene data
PABPC1- Name
- poly(A) binding protein cytoplasmic 1
- Type
- protein-coding
- Aliases
- PAB1, PABP, PABP1, PABPC2, PABPL1
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010].
via MyGene.info
Gene · Ensembl
poly(A) binding protein cytoplasmic 1
- Symbol
- PABPC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:100,685,816-100,722,809
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PABPC1 PDB 1cvj.png
Show 5 more facts
- HomoloGene ID
- 37638
- exact match
- identifiers.org/ncbigene/26986
- genomic start
- 101698044
- genomic end
- 101735037
- cytogenetic location
- 8q22.3
Sources (4)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability. There are two separate PABP1 proteins, one which is located in the nucleus (PABPN1) and the other which is found in the cytoplasm (PABPC1). The location of PABP1 affects the role of that protein and its function with RNA.
== Function ==