ANAPC5

Also known as APC5, anaphase promoting complex subunit 5

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to ANAPC5, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Vinony links it to 6 Wikipedia language editions.

Gene data

ANAPC5

Name: anaphase promoting complex subunit 5
Type: protein-coding
Position: 121,308,243–121,399,896 (−)
Aliases: APC5
Ensembl: ENSG00000089053
RefSeq RNA: NM_001137559.1, NM_001330489.2, NM_016237.5
RefSeq protein: NP_001131031.1, NP_001317418.1, NP_057321.2

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008].

Gene Ontology

Biological process

regulation of mitotic cell cycle protein ubiquitination anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process positive regulation of mitotic metaphase/anaphase transition regulation of meiotic cell cycle protein K48-linked ubiquitination

Molecular function

protein phosphatase binding

Cellular component

nucleus nucleus nucleoplasm anaphase-promoting complex anaphase-promoting complex anaphase-promoting complex anaphase-promoting complex anaphase-promoting complex

Pathways

Cell cycle - Homo sapiens (human)Oocyte meiosis - Homo sapiens (human)Ubiquitin mediated proteolysis - Homo sapiens (human)IL-17 signaling pathway - Homo sapiens (human)Progesterone-mediated oocyte maturation - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Adaptive Immune System Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Cell Cycle

via MyGene.info

Gene · Ensembl

anaphase promoting complex subunit 5

Symbol: ANAPC5
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:121,308,243-121,399,896
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 41118
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/51433
chromosome: human chromosome 12
genomic start: 121746048
genomic end: 121837699
cytogenetic location: 12q24.31

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

Interactions
References
External links
Further reading

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM]

Excerpted from Wikipedia’s “ANAPC5” article, available under the CC BY-SA 4.0 licence.