ANAPC1

Also known as APC1, MCPR, TSG24, anaphase promoting complex subunit 1

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

In the Vinony graph

Within Vinony's link graph, ANAPC1 is referenced by 6 other articles, and connects out to PubMed, Online Mendelian Inheritance in Man and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ANAPC1

Name: anaphase promoting complex subunit 1
Type: protein-coding
Position: 111,611,639–111,884,690 (−)
Aliases: APC1, MCPR, TSG24
Ensembl: ENSG00000153107
RefSeq RNA: NM_022662.4, XM_011511633.3, XM_011511634.3, XM_017004710.3, XM_017004711.2
RefSeq protein: NP_073153.1, XP_011509935.1, XP_011509936.1, XP_016860199.1, XP_016860200.1

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].

Gene Ontology

Biological process

metaphase/anaphase transition of mitotic cell cycle regulation of mitotic cell cycle protein ubiquitination anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process anaphase-promoting complex-dependent catabolic process regulation of meiotic cell cycle protein K48-linked ubiquitination

Molecular function

molecular adaptor activity

Cellular component

nucleus nucleoplasm anaphase-promoting complex anaphase-promoting complex anaphase-promoting complex anaphase-promoting complex anaphase-promoting complex cytosol

Pathways

Cell cycle - Homo sapiens (human)Oocyte meiosis - Homo sapiens (human)Ubiquitin mediated proteolysis - Homo sapiens (human)Progesterone-mediated oocyte maturation - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Adaptive Immune System Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Cell Cycle Disease

via MyGene.info

Gene · Ensembl

anaphase promoting complex subunit 1

Symbol: ANAPC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:111,611,639-111,884,690
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 7414
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/64682
genomic end: 112642267
genomic start: 111611639
chromosome: human chromosome 2
cytogenetic location: 2q13

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Interactions
References
External links
Further reading

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).

Excerpted from Wikipedia’s “ANAPC1” article, available under the CC BY-SA 4.0 licence.