NAE1

Name

NEDD8 activating enzyme E1 subunit 1

Type

protein-coding

Position

66,802,874–66,873,256 (−)

Aliases

A-116A10.1, APPBP1, HPP1, NEDFIH, ula-1

Ensembl

ENSG00000159593

RefSeq RNA

NM_001018159.2, NM_001018160.2, NM_001286500.2, NM_003905.4, XM_047434835.1

RefSeq protein

NP_001018169.1, NP_001018170.1, NP_001273429.1, NP_003896.1, XP_047290791.1

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

NEDD8 activating enzyme E1 subunit 1

Symbol

NAE1

Biotype

Protein coding

Organism

Homo sapiens

Location

16:66,802,874-66,873,256

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein APPBP1 PDB 1r4m.png

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