ANAPC2
Sign in to saveAlso known as APC2, anaphase promoting complex subunit 2
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.
In the Vinony graph
Within Vinony's link graph, ANAPC2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 7 Wikipedia language editions.
Gene data
ANAPC2- Name
- anaphase promoting complex subunit 2
- Type
- protein-coding
- Aliases
- APC2
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
anaphase promoting complex subunit 2
- Symbol
- ANAPC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:137,174,784-137,189,028
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 8359
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29882
- genomic end
- 137188560
- genomic start
- 140069236
- chromosome
- human chromosome 9
- cytogenetic location
- 9q34.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- External links
- Further reading
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.
Excerpted from Wikipedia’s “ANAPC2” article, available under the CC BY-SA 4.0 licence.