ERAP2
Sign in to saveAlso known as L-RAP, LRAP, endoplasmic reticulum aminopeptidase 2
Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a protein that in humans is encoded by the ERAP2 gene. ERAP2 is part of the M1 aminopeptidase family. It is expressed along with ERAP1 in the endoplasmic reticulum (ER). In the ER, both enzymes help process and present antigens by trimming the ends of precursor peptides. This creates the optimal pieces for display by Major Histocompatibility Complex (MHC) class I molecules.
Gene data
ERAP2- Name
- endoplasmic reticulum aminopeptidase 2
- Type
- protein-coding
- Position
- 96,875,986–96,919,703 (+)
- Aliases
- L-RAP, LRAP
- Ensembl
- ENSG00000164308
- RefSeq RNA
- NM_001130140.3, NM_001329229.2, NM_001329233.2, NM_001437802.1, NM_001438758.1
- RefSeq protein
- NP_001123612.1, NP_001316158.1, NP_001316162.1, NP_001424731.1, NP_001425687.1
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
endoplasmic reticulum aminopeptidase 2
- Symbol
- ERAP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:96,875,979-96,919,703
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Crystal structure ERAP2 - PDB 3SE6.jpg
Show 6 more facts
- HomoloGene ID
- 75183
- exact match
- identifiers.org/ncbigene/64167
- genomic end
- 96919703
- genomic start
- 96875986
- cytogenetic location
- 5q15
- Commons category
- ERAP2
Sources (3)
via Wikidata · CC0
~11 min read
Article
15 sectionsContents
- Biology / Functions
- Expression
- Antigen presentation
- Other functions
- Genetics / clinical significance
- Gene / location
- SNPs and disease association
- Structure / Mechanism
- Structure
- Mechanism
- Interactions
- Therapeutic approaches and pharmacology
- ERAP2 catalytic site inhibitors
- ERAP2 allosteric site inhibitors
- References
Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a protein that in humans is encoded by the ERAP2 gene. ERAP2 is part of the M1 aminopeptidase family. It is expressed along with ERAP1 in the endoplasmic reticulum (ER). In the ER, both enzymes help process and present antigens by trimming the ends of precursor peptides. This creates the optimal pieces for display by Major Histocompatibility Complex (MHC) class I molecules.
== Biology / Functions ==