ERAP1
Sign in to saveAlso known as A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that in humans is encoded by the ERAP1 gene. This M1 zinc aminopeptidase is involved in the antigen processing and presentation pathway. ERAP1 is mainly located in the endoplasmic reticulum (ER), where it trims peptides at their N-terminus, adapting them for presentation by MHC class I molecules (MHC-I).
Gene data
ERAP1- Name
- endoplasmic reticulum aminopeptidase 1
- Type
- protein-coding
- Aliases
- A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
via MyGene.info
Gene · Ensembl
endoplasmic reticulum aminopeptidase 1
- Symbol
- ERAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:96,759,649-96,808,177
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 3QNF.pdb.png
Show 5 more facts
- exact match
- identifiers.org/ncbigene/51752
- genomic end
- 96143803
- genomic start
- 96096521
- cytogenetic location
- 5q15
- HomoloGene ID
- 140581
via Wikidata · CC0
~14 min read
Article
15 sectionsContents
- Nomenclature
- Biology / Functions
- Genetics / Clinical significance
- Gene / location
- SNPs
- Disease association
- Structure / Mechanism
- Structure
- Mechanism
- Interactions
- Therapeutic approaches and pharmacology
- ERAP1 catalytic site inhibitors
- ERAP1 allosteric site inhibitors
- Clinical trials
- References
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that in humans is encoded by the ERAP1 gene. This M1 zinc aminopeptidase is involved in the antigen processing and presentation pathway. ERAP1 is mainly located in the endoplasmic reticulum (ER), where it trims peptides at their N-terminus, adapting them for presentation by MHC class I molecules (MHC-I).
== Nomenclature == Historical names of ERAP1, [HUGO Gene Nomenclature Committee]: Aminopeptidase regulator of tumour necrosis factor receptor 1 (TNFR1) shedding (ARTS-1) Adipocyte-derived leucine aminopeptidase (A-LAP) Puromycin-insensitive leucyl-specific aminopeptidase (PILS-AP) KIAA0525 In mice, ER aminopeptidase associated with antigen processing (ERAAP)