METAP2

Name

methionyl aminopeptidase 2

Type

protein-coding

Aliases

MAP2, MNPEP, p67eIF2

The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

methionyl aminopeptidase 2

Symbol

METAP2

Biotype

Protein coding

Organism

Homo sapiens

Location

12:95,473,520-95,515,935

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein METAP2 PDB 1b59.png

via Wikidata · CC0