ACP2
Sign in to saveAlso known as acid phosphatase 2, lysosomal, LAP
Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.
In the Vinony graph
Vinony's link graph records 6 inbound references to ACP2, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 11 and Human proteins.
Vinony links it to 4 Wikipedia language editions.
Gene data
ACP2- Name
- acid phosphatase 2, lysosomal
- Type
- protein-coding
- Position
- 47,237,598–47,249,288 (−)
- Aliases
- LAP
- Ensembl
- ENSG00000134575
- RefSeq RNA
- NM_001131064.1, NM_001302489.2, NM_001302490.2, NM_001302491.2, NM_001302492.2
- RefSeq protein
- NP_001289418.1, NP_001289419.1, NP_001289420.1, NP_001289421.1, NP_001343945.1
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
acid phosphatase 2, lysosomal
- Symbol
- ACP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:47,237,598-47,249,288
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1217
- exact match
- identifiers.org/ncbigene/53
- found in taxon
- Homo sapiens
- genomic end
- 47248906
- genomic start
- 47239302
- chromosome
- human chromosome 11
- cytogenetic location
- 11p11.2|11p12-p11
- expressed in
- salivary gland
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.
Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.
Excerpted from Wikipedia’s “ACP2” article, available under the CC BY-SA 4.0 licence.