ACP1
Sign in to saveAlso known as HAAP, LMW-PTP, acid phosphatase 1, soluble, LMWPTP, acid phosphatase 1
Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.
In the Vinony graph
Within Vinony's link graph, ACP1 is referenced by 86 other articles, and connects out to PubMed, Ensembl genome database project and enzyme.
Vinony files it under Genes on human chromosome 2 and Human proteins.
Its subject is documented across 4 Wikipedia language editions.
Gene data
ACP1- Name
- acid phosphatase 1
- Type
- protein-coding
- Position
- 264,140–280,057 (+)
- Aliases
- HAAP, LMW-PTP, LMWPTP
- Ensembl
- ENSG00000143727
- RefSeq RNA
- NM_001040649.3, NM_004300.4, NM_007099.4, NM_177554.1, NR_024080.2
- RefSeq protein
- NP_001035739.1, NP_004291.1, NP_009030.1
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
acid phosphatase 1
- Symbol
- ACP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:264,140-280,057
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ACP1 PDB 1bvh.png
Show 8 more facts
- HomoloGene ID
- 38274
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/52
- genomic end
- 278283
- genomic start
- 264140
- chromosome
- human chromosome 2
- cytogenetic location
- 2p25.3
- expressed in
- embryo
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Clinical significance
- Interactions
- References
- External links
- Further reading
Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.
Excerpted from Wikipedia’s “ACP1” article, available under the CC BY-SA 4.0 licence.