M-phase inducer phosphatase
Sign in to saveAlso known as Cdc25 phosphatase
Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. As with other cell cycle proteins or genes such as Cdc2 and Cdc4, the "cdc" in its name refers to "cell division cycle". Dual-specificity phosphatases are considered a sub-class of protein tyrosine phosphatases. By removing inhibitory phosphate residues from target cyclin-dependent kinases (Cdks), Cdc25 proteins control entry into and progression through various phases of the cell cycle, including mitosis and S ("Synthesis") phase.
Protein · UniProt
M-phase inducer phosphatase
- Gene
- cdc25
- Organism
- Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
- Length
- 596 aa
- Molecular mass
- 66,566 Da
- Evidence
- 1: Evidence at protein level
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic and meiotic progression (PubMed:3955656, PubMed:7498766, Ref.3). Directly dephosphorylates cdc2 and stimulates its kinase activity (By similarity). Required for the G2/M transition of the cell cycle (PubMed:15629716). Required for induction of meiosis II (PubMed:7498766, Ref.3)
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
- Subclass of
- phosphatase
Show 2 more facts
- found in taxon
- Schizosaccharomyces pombe
- EC enzyme number
- 3.1.3.48
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
9 sectionsContents
- Function in activating Cdk1
- Structure
- Evolution and species distribution
- Knockout models
- In human disease
- See also
- References
- External links
- Genes
Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. As with other cell cycle proteins or genes such as Cdc2 and Cdc4, the "cdc" in its name refers to "cell division cycle". Dual-specificity phosphatases are considered a sub-class of protein tyrosine phosphatases. By removing inhibitory phosphate residues from target cyclin-dependent kinases (Cdks), Cdc25 proteins control entry into and progression through various phases of the cell cycle, including mitosis and S ("Synthesis") phase.
==Function in activating Cdk1== Cdc25 activates cyclin dependent kinases by removing phosphate from residues in the Cdk active site. In turn, the phosphorylation by M-Cdk (a complex of Cdk1 and cyclin B) activates Cdc25. Together with Wee1, M-Cdk activation is switch-like. The switch-like behavior forces entry into mitosis to be quick and irreversible. Cdk activity can be reactivated after dephosphorylation by Cdc25. The Cdc25 enzymes Cdc25A-C are known to control the transitions from G1 to S phase and G2 to M phase.
Excerpted from Wikipedia’s “M-phase inducer phosphatase” article, available under the CC BY-SA 4.0 licence.