RASGRF1
Sign in to saveAlso known as CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.
Gene data
RASGRF1- Name
- Ras protein specific guanine nucleotide releasing factor 1
- Type
- protein-coding
- Position
- 78,959,906–79,090,930 (−)
- Aliases
- CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1
- Ensembl
- ENSG00000058335
- RefSeq RNA
- NM_001145648.3, NM_002891.6, NM_153815.3, XM_011521866.4, XM_017022455.3
- RefSeq protein
- NP_001139120.1, NP_002882.3, NP_722522.1, XP_011520168.1, XP_016877944.1
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Ras protein specific guanine nucleotide releasing factor 1
- Symbol
- RASGRF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:78,959,906-79,090,930
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 74972
- genomic end
- 79090780
- genetic association
- refractive error
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5923
- chromosome
- human chromosome 15
- genomic start
- 78959906
- cytogenetic location
- 15q25.1
- expressed in
- superior frontal gyrus
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.
Excerpted from Wikipedia’s “RASGRF1” article, available under the CC BY-SA 4.0 licence.