RASGRF1
Sign in to saveAlso known as CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.
Gene data
RASGRF1- Name
- Ras protein specific guanine nucleotide releasing factor 1
- Type
- protein-coding
- Aliases
- CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].
via MyGene.info
Gene · Ensembl
Ras protein specific guanine nucleotide releasing factor 1
- Symbol
- RASGRF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:78,959,906-79,090,930
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 74972
- genomic end
- 79090780
- exact match
- identifiers.org/ncbigene/5923
- genomic start
- 78959906
- cytogenetic location
- 15q25.1
via Wikidata · CC0
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Article
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- Further reading
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.