Wee1
Sign in to saveWee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression.
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~13 min read
Article
15 sectionsContents
- Introduction
- Discovery / History
- Function
- Homologues
- Regulation
- Role in cancer
- Wee1 as a target in oncology
- Wee1 expression in tumors
- Wee1 inhibitors
- Clinical development
- Mutant phenotype
- See also
- Notes
- References
- External links
Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression.
It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.
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