PPP1R8
Sign in to saveAlso known as ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8
Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.
Gene data
PPP1R8- Name
- protein phosphatase 1 regulatory subunit 8
- Type
- protein-coding
- Position
- 27,830,763–27,851,676 (+)
- Aliases
- ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
- Ensembl
- ENSG00000117751
- RefSeq RNA
- NM_002713.4, NM_014110.5, NM_138558.3
- RefSeq protein
- NP_002704.1, NP_054829.2, NP_612568.1
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 1 regulatory subunit 8
- Symbol
- PPP1R8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:27,830,763-27,851,676
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Excerpted from Wikipedia’s “PPP1R8” article, available under the CC BY-SA 4.0 licence.