SF3B1

Name

splicing factor 3b subunit 1

Type

protein-coding

Position

197,388,515–197,435,079 (−)

Aliases

Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155

Ensembl

ENSG00000115524

RefSeq RNA

NM_001005526.2, NM_001308824.1, NM_012433.4, XM_047443838.1, XM_047443839.1

RefSeq protein

NP_001005526.1, NP_001295753.1, NP_036565.2, XP_047299794.1, XP_047299795.1

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

splicing factor 3b subunit 1

Symbol

SF3B1

Biotype

Protein coding

Organism

Homo sapiens

Location

2:197,388,515-197,435,079

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein SF3B1 PDB 2f9d.png

via Wikidata · CC0