EED

Name

embryonic ectoderm development

Type

protein-coding

Position

86,201,212–86,279,807 (+)

Aliases

COGIS, HEED, WAIT1

Ensembl

ENSG00000074266

RefSeq RNA

NM_001308007.2, NM_001330334.2, NM_001440586.1, NM_001440587.1, NM_001440588.1

RefSeq protein

NP_001294936.1, NP_001317263.1, NP_001427515.1, NP_001427516.1, NP_001427517.1

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].