EED

Also known as HEED, WAIT1, embryonic ectoderm development, COGIS

protein-coding gene in the species Homo sapiens

Gene data

EED

Name: embryonic ectoderm development
Type: protein-coding
Position: 86,201,212–86,279,807 (+)
Aliases: COGIS, HEED, WAIT1
Ensembl: ENSG00000074266
RefSeq RNA: NM_001308007.2, NM_001330334.2, NM_001440586.1, NM_001440587.1, NM_001440588.1
RefSeq protein: NP_001294936.1, NP_001317263.1, NP_001427515.1, NP_001427516.1, NP_001427517.1

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].