SNAI2
Sign in to saveAlso known as SLUG, SLUGH1, SNAIL2, WS2D, snail family transcriptional repressor 2, SLUGH
Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes epithelial to mesenchymal transition, differentiation (e.g. in gastrulation), and migration of cells.
Gene data
SNAI2- Name
- snail family transcriptional repressor 2
- Type
- protein-coding
- Aliases
- SLUG, SLUGH, SLUGH1, SNAIL2, WS2D
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
snail family transcriptional repressor 2
- Symbol
- SNAI2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:48,917,284-48,921,740
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 31127
- exact match
- identifiers.org/ncbigene/6591
- genomic end
- 49834299
- genomic start
- 48917598
- cytogenetic location
- 8q11.21
Sources (4)
via Wikidata · CC0
~4 min read
Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- Snail2 and PRC2 in Neural Crest Development
- References
- Further reading
Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes epithelial to mesenchymal transition, differentiation (e.g. in gastrulation), and migration of cells.
== Function ==