PAX7
Sign in to saveAlso known as HUP1, PAX7B, RMS2, paired box 7, MYOSCO
Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.
Gene data
PAX7- Name
- paired box 7
- Type
- protein-coding
- Aliases
- CMYO19, CMYP19, HUP1, MYOSCO, PAX7B, RMS2
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
via MyGene.info
Gene · Ensembl
paired box 7
- Symbol
- PAX7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:18,630,846-18,748,876
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 55665
- exact match
- identifiers.org/ncbigene/5081
- genomic end
- 19075360
- genomic start
- 18630846
- cytogenetic location
- 1p36.13
Sources (4)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Clinical significance
- See also
- References
- Further reading
- External links
Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.
== Function == Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. PAX7 is expressed in the palatal shelf of the maxilla, Meckel's cartilage, mesencephalon, nasal cavity, nasal epithelium, nasal capsule and pons.