PAX7

Also known as HUP1, PAX7B, RMS2, paired box 7, MYOSCO

Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.

In the Vinony graph

Within Vinony's link graph, PAX7 is referenced by 929 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 1 and Transcription factors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

PAX7

Name: paired box 7
Type: protein-coding
Position: 18,630,846–18,748,876 (+)
Aliases: CMYO19, CMYP19, HUP1, MYOSCO, PAX7B, RMS2
Ensembl: ENSG00000009709
RefSeq RNA: NM_001135254.2, NM_002584.3, NM_013945.3
RefSeq protein: NP_001128726.1, NP_002575.1, NP_039236.1

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II nervous system development anatomical structure morphogenesis anatomical structure morphogenesis skeletal muscle satellite cell differentiation skeletal muscle satellite cell differentiation negative regulation of apoptotic process

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus

Pathways

Transcriptional misregulation in cancer - Homo sapiens (human)Developmental Biology Gastrulation Specification of the neural plate border Cell Differentiation - Index expanded Neural Crest Differentiation

via MyGene.info

Gene · Ensembl

paired box 7

Symbol: PAX7
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:18,630,846-18,748,876
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 55665
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5081
genomic end: 19075360
genomic start: 18630846
chromosome: human chromosome 1
cytogenetic location: 1p36.13
expressed in: cingulate gyrus

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections

Contents

Function
Clinical significance
See also
References
Further reading
External links

Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.

== Function == Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. PAX7 is expressed in the palatal shelf of the maxilla, Meckel's cartilage, mesencephalon, nasal cavity, nasal epithelium, nasal capsule and pons.

Excerpted from Wikipedia’s “PAX7” article, available under the CC BY-SA 4.0 licence.