HDAC1

Name

histone deacetylase 1

Type

protein-coding

Position

32,291,921–32,333,635 (+)

Aliases

GON-10, HD1, KDAC1, RPD3, RPD3L1

Ensembl

ENSG00000116478

RefSeq RNA

NM_004964.3, XM_011541309.3, XM_054336203.1

RefSeq protein

NP_004955.2, XP_011539611.1, XP_054192178.1

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

histone deacetylase 1

Symbol

HDAC1

Biotype

Protein coding

Organism

Homo sapiens

Location

1:32,291,919-32,333,635

Strand

Forward (+)

Assembly

GRCh38

• HDAC1: an environmental sensor regulating endothelial function.Cardiovascular research · 2022
• The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity.Cell reports · 2024
• Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2023
• Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.Journal of neuroinflammation · 2021
• HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation.Cell discovery · 2023

via PubMed

Wikidata facts

via Wikidata · CC0