ZBTB16

Name

zinc finger and BTB domain containing 16

Type

protein-coding

Position

114,058,335–114,256,765 (+)

Aliases

PLZF, ZNF145

Ensembl

ENSG00000109906

RefSeq RNA

NM_001018011.3, NM_001354750.2, NM_001354751.2, NM_001354752.1, NM_006006.6

RefSeq protein

NP_001018011.1, NP_001341679.1, NP_001341680.1, NP_001341681.1, NP_005997.2

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].