MICB

Also known as PERB11.2, MHC class I polypeptide-related sequence B

protein-coding gene in the species Homo sapiens

Gene data

MICB

Name: MHC class I polypeptide-related sequence B
Type: protein-coding
Chromosome: HSCHR6_MHC_QBL_CTG1
Aliases: PERB11.2

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

via MyGene.info