MICB
Sign in to saveAlso known as PERB11.2, MHC class I polypeptide-related sequence B
protein-coding gene in the species Homo sapiens
In the Vinony graph
Vinony's link graph records 11 inbound references to MICB, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 6.
Vinony links it to 5 Wikipedia language editions.
Gene data
MICB- Name
- MHC class I polypeptide-related sequence B
- Type
- protein-coding
- Position
- 31,494,881–31,511,124 (+)
- Aliases
- PERB11.2
- Ensembl
- ENSG00000224378
- RefSeq RNA
- NM_001289160.2, NM_001289161.2, NM_005931.5, XM_054328503.1, XM_054330825.1
- RefSeq protein
- NP_001276089.1, NP_001276090.1, NP_005922.2, XP_054184478.1, XP_054186800.1
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MHC class I polypeptide-related sequence B
- Symbol
- MICB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_APD_CTG1:2,827,449-2,843,674
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MICB PDB 1je6.png
Show 8 more facts
- HomoloGene ID
- 88329
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4277
- chromosome
- human chromosome 6
- genomic start
- 31462658
- genomic end
- 31478901
- cytogenetic location
- 6p21.33
- expressed in
- appendix
via Wikidata · CC0