PLA2G4A

Name

phospholipase A2 group IVA

Type

protein-coding

Position

186,828,949–186,988,986 (+)

Aliases

GURDP, PLA2G4, cPLA2, cPLA2-alpha

Ensembl

ENSG00000116711

RefSeq RNA

NM_001311193.2, NM_024420.3, XM_005245267.5, XM_011509642.3, XM_047422599.1

RefSeq protein

NP_001298122.2, NP_077734.2, XP_005245324.2, XP_011507944.1, XP_047278555.1

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].