PLA2G4A
Sign in to saveAlso known as PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.
In the Vinony graph
Within Vinony's link graph, PLA2G4A is referenced by 10 other articles, and connects out to PubMed, Ensembl genome database project and enzyme.
Vinony files it under EC 3.1.1 and Genes on human chromosome 1.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PLA2G4A- Name
- phospholipase A2 group IVA
- Type
- protein-coding
- Position
- 186,828,949–186,989,902 (+)
- Aliases
- GURDP, PLA2G4, cPLA2, cPLA2-alpha
- Ensembl
- ENSG00000116711
- RefSeq RNA
- NM_001311193.2, NM_024420.3, XM_005245267.5, XM_011509642.3, XM_047422599.1
- RefSeq protein
- NP_001298122.2, NP_077734.2, XP_005245324.2, XP_011507944.1, XP_047278555.1
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
phospholipase A2 group IVA
- Symbol
- PLA2G4A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:186,828,949-186,989,902
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PLA2G4A PDB 1bci.png
Show 8 more facts
- HomoloGene ID
- 32059
- genetic association
- epilepsy
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5321
- genomic end
- 186958113
- genomic start
- 186828949
- chromosome
- human chromosome 1
- cytogenetic location
- 1q31.1
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- Clinical significance
- References
- Further reading
Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.
== Function ==
Excerpted from Wikipedia’s “PLA2G4A” article, available under the CC BY-SA 4.0 licence.