EIF4G1

Also known as EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, Eukaryotic translation initiation factor 4 gamma, eukaryotic translation initiation factor 4 gamma 1

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 224 inbound references to EIF4G1, and connects out to PubMed, translation and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 3.

Vinony links it to 5 Wikipedia language editions.

Gene data

EIF4G1

Name: eukaryotic translation initiation factor 4 gamma 1
Type: protein-coding
Position: 184,314,490–184,335,358 (+)
Aliases: EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
Ensembl: ENSG00000114867
RefSeq RNA: NM_001194946.2, NM_001194947.2, NM_001291157.2, NM_004953.5, NM_182917.4
RefSeq protein: NP_001181875.2, NP_001181876.2, NP_001278086.2, NP_004944.3, NP_886553.3

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].